… studies, whereupon CXCR3, CXCR4, and ACKR3 small-molecule ligands were competed
for binding against the radiolabeled agonist. Interestingly, the chemokine ligands CXCL11 …

… chemokine ligands and 20 chemokine receptors have been identified, but, to date, only two
small molecule chemokine receptor … The chemokine receptor CXCR3 was identified in 1996, …

… of leukocyte migration by interfering with chemokine receptor signaling is an attractive … both
academia and the pharmaceutical industry. The chemokine receptor CXCR3 is expressed by …

… (16) Besides this, the development of small-molecule agonists of CXCR3 was largely … We
combined this approach with detailed pharmacological characterization of novel compounds …

… ligands and their pharmacological characterization for modulation of chemokine receptors.
Ligands … Thus, the noncompetitive nature of these small molecule antagonists at CXCR3 and …

… SIGNIFICANCE STATEMENT We are interested in the signaling produced by the G protein
coupled receptor atypical chemokine receptor 3 (ACKR3), which signals atypically. In this …

… Photochemical and pharmacological characterisation of ligands 3a-l were performed in …
Ability of inhibition of agonist-induced β-arrestin2 recruitment to indicated chemokine receptors …

… bind to chemokines. The development of drugs acting on chemokine receptors has been
challenging.At present, two small-molecule drugs targeting chemokine receptors have been …

… Small molecule and antibody-based antagonists have been … Displacement binding allows
pharmacological characterization of … -dependent manner in CXCR3-expressing HEK293 cells. …

… CXCR3 chemokine receptors and remains unaltered up to 2 h in human serum. Moreover,
NMR and advanced molecular modeling studies allowed us to define the structural reasons …